Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)
Identifieur interne : 000077 ( France/Analysis ); précédent : 000076; suivant : 000078Ependymitis, leukoencephalitis, hydrocephalus, and thrombotic vasculitis following chronic infection by mouse hepatitis virus 3 (MHV 3)
Auteurs : M. Tardieu [Belgique, France] ; A. Goffinet [Belgique] ; G. Harmant-Van Rijckevorsel [Belgique] ; G. Lyon [Belgique]Source :
- Acta Neuropathologica [ 0001-6322 ] ; 1982-09-01.
English descriptors
- KwdEn :
- Teeft :
- Acta, Acta neuropathol, Acute hepatic necrosis, Adjacent cortex, Adult mice, Aqueductal stenosis, Arch neurol, Chronic disease, Chronic infection, Chronic thrombotic vasculitis, Congenital rubella syndrome, Cyclophosphamide, Cyclophosphamide treatment, Days semithin section, Demyelination, Diffuse meningeal, Direct action, Dupuy, Electron microscope, Ependymal, Ependymal cell line, Ependymal cells, Ependymal lesions, Ependymitis, Fourth ventricle, Genetic factors, Genetic resistance, Granulomatous angiitis, Host cells, Hyaline necrosis, Hydrocephalus, Immunol, Infection, Inflammatory, Inflammatory cells, Inflammatory lesions, Inflammatory thrombus, Intracranial inoculation, Ischemic necrosis, Lesion, Leukoencephalitis, Meningeal, Microglial nodules, Mononuclear cells, Mouse, Mouse hepatitis virus, Mouse hepatitis virus type, Necrosis, Necrotic cells, Nervous system, Neurol, Neuropathol, Neuropathologic, Particular interest, Perivascular, Phosphate buffer, Plasmocytes, Prevost, Proc natl acad, Resistant mice, Saline buffer, Second injection, Semisusceptible, Semisusceptible animals, Semisusceptible mice, Semisusceptible strains, Small lymphocytes, Strain mice, Susceptible mice, Tardieu, Thrombotic, Thrombotic vasculitis, Vascular lesions, Vascular occlusions, Vasculitis, Ventricular dilatation, Vessel walls, Viral, Viral infections, Viral particles, Virus infection, Weiner, White matter, Widespread destruction.
Abstract
Summary: Mouse hepatitis virus 3 (MHV 3) is either avirulent (resistant mice), hepatotropic (susceptible mice). or neurotropic (semisusceptible mice), depending on the strain of mice infected. In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level. Small foci of ischemic necrosis related to vascular occlusions were seen in the dorsal brain stem. Cyclophosphamide treatment of semisusceptible mice significantly reduced the meningeal infiltrates but did not prevent the development of hydrocephalus and other neuropathologic changes. Identical lesions occurred in fully susceptible mice infected with a low dose of virus, but no neurologic disorder could be induced in genetically resistant mice even following immunosuppression or intracranial inoculation. The leukoencephalitis differed from the demyelinating lesions observed with MHV4. Vascular lesions were of particular interest. More attention should be given to the possibifity of virus induced chronic cerebral vasculitis in man.
Url:
DOI: 10.1007/BF00690797
Affiliations:
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ISTEX:99169036D68B6D65B61177EC6EACE45A766C7BACLe document en format XML
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Harmant-Van Rijckevorsel</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Belgique</country><wicri:regionArea>Chargé de Recherche of the FNRS</wicri:regionArea></affiliation></author><author><name sortKey="Lyon, G" sort="Lyon, G" uniqKey="Lyon G" first="G." last="Lyon">G. Lyon</name><affiliation wicri:level="3"><country xml:lang="fr">Belgique</country><wicri:regionArea>Unité de Neurologie du Développement, Université de Louvain, Ecole de Médecine, Bruxelles</wicri:regionArea><placeName><settlement type="city">Bruxelles</settlement><region nuts="2">Région de Bruxelles-Capitale</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Acta Neuropathologica</title><title level="j" type="abbrev">Acta Neuropathol</title><idno type="ISSN">0001-6322</idno><idno type="eISSN">1432-0533</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1982-09-01">1982-09-01</date><biblScope unit="volume">58</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="168">168</biblScope><biblScope unit="page" to="176">176</biblScope></imprint><idno type="ISSN">0001-6322</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-6322</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Experimental hydrocephalus</term><term>Experimental leukoencephalitis</term><term>MHV 3</term><term>Viral vasculitis</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acta</term><term>Acta neuropathol</term><term>Acute hepatic necrosis</term><term>Adjacent cortex</term><term>Adult mice</term><term>Aqueductal stenosis</term><term>Arch neurol</term><term>Chronic disease</term><term>Chronic infection</term><term>Chronic thrombotic vasculitis</term><term>Congenital rubella syndrome</term><term>Cyclophosphamide</term><term>Cyclophosphamide treatment</term><term>Days semithin section</term><term>Demyelination</term><term>Diffuse meningeal</term><term>Direct action</term><term>Dupuy</term><term>Electron microscope</term><term>Ependymal</term><term>Ependymal cell line</term><term>Ependymal cells</term><term>Ependymal lesions</term><term>Ependymitis</term><term>Fourth ventricle</term><term>Genetic factors</term><term>Genetic resistance</term><term>Granulomatous angiitis</term><term>Host cells</term><term>Hyaline necrosis</term><term>Hydrocephalus</term><term>Immunol</term><term>Infection</term><term>Inflammatory</term><term>Inflammatory cells</term><term>Inflammatory lesions</term><term>Inflammatory thrombus</term><term>Intracranial inoculation</term><term>Ischemic necrosis</term><term>Lesion</term><term>Leukoencephalitis</term><term>Meningeal</term><term>Microglial nodules</term><term>Mononuclear cells</term><term>Mouse</term><term>Mouse hepatitis virus</term><term>Mouse hepatitis virus type</term><term>Necrosis</term><term>Necrotic cells</term><term>Nervous system</term><term>Neurol</term><term>Neuropathol</term><term>Neuropathologic</term><term>Particular interest</term><term>Perivascular</term><term>Phosphate buffer</term><term>Plasmocytes</term><term>Prevost</term><term>Proc natl acad</term><term>Resistant mice</term><term>Saline buffer</term><term>Second injection</term><term>Semisusceptible</term><term>Semisusceptible animals</term><term>Semisusceptible mice</term><term>Semisusceptible strains</term><term>Small lymphocytes</term><term>Strain mice</term><term>Susceptible mice</term><term>Tardieu</term><term>Thrombotic</term><term>Thrombotic vasculitis</term><term>Vascular lesions</term><term>Vascular occlusions</term><term>Vasculitis</term><term>Ventricular dilatation</term><term>Vessel walls</term><term>Viral</term><term>Viral infections</term><term>Viral particles</term><term>Virus infection</term><term>Weiner</term><term>White matter</term><term>Widespread destruction</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: Mouse hepatitis virus 3 (MHV 3) is either avirulent (resistant mice), hepatotropic (susceptible mice). or neurotropic (semisusceptible mice), depending on the strain of mice infected. In semisusceptible mice, infection led first to a transient meningitis, ependymitis, and leukoencephalitis, followed by a permanent communicating hydrocephalus and, later on, to a chronic thrombotic vasculitis affecting meningeal and parenchymal vessels at the brain stem level. Small foci of ischemic necrosis related to vascular occlusions were seen in the dorsal brain stem. Cyclophosphamide treatment of semisusceptible mice significantly reduced the meningeal infiltrates but did not prevent the development of hydrocephalus and other neuropathologic changes. Identical lesions occurred in fully susceptible mice infected with a low dose of virus, but no neurologic disorder could be induced in genetically resistant mice even following immunosuppression or intracranial inoculation. The leukoencephalitis differed from the demyelinating lesions observed with MHV4. Vascular lesions were of particular interest. More attention should be given to the possibifity of virus induced chronic cerebral vasculitis in man.</div></front></TEI><affiliations><list><country><li>Belgique</li><li>France</li></country><region><li>Région de Bruxelles-Capitale</li><li>Île-de-France</li></region><settlement><li>Bicêtre</li><li>Bruxelles</li></settlement></list><tree><country name="Belgique"><region name="Région de Bruxelles-Capitale"><name sortKey="Tardieu, M" sort="Tardieu, M" uniqKey="Tardieu M" first="M." last="Tardieu">M. Tardieu</name></region><name sortKey="Goffinet, A" sort="Goffinet, A" uniqKey="Goffinet A" first="A." last="Goffinet">A. Goffinet</name><name sortKey="Goffinet, A" sort="Goffinet, A" uniqKey="Goffinet A" first="A." last="Goffinet">A. Goffinet</name><name sortKey="Harmant Van Rijckevorsel, G" sort="Harmant Van Rijckevorsel, G" uniqKey="Harmant Van Rijckevorsel G" first="G." last="Harmant-Van Rijckevorsel">G. Harmant-Van Rijckevorsel</name><name sortKey="Harmant Van Rijckevorsel, G" sort="Harmant Van Rijckevorsel, G" uniqKey="Harmant Van Rijckevorsel G" first="G." last="Harmant-Van Rijckevorsel">G. Harmant-Van Rijckevorsel</name><name sortKey="Lyon, G" sort="Lyon, G" uniqKey="Lyon G" first="G." last="Lyon">G. Lyon</name></country><country name="France"><region name="Île-de-France"><name sortKey="Tardieu, M" sort="Tardieu, M" uniqKey="Tardieu M" first="M." last="Tardieu">M. Tardieu</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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